WHO rapid advice guidelines for pharmacological management of sporadic human infection with avian influenza A (H5N1) virus
Identifieur interne : 009252 ( Main/Exploration ); précédent : 009251; suivant : 009253WHO rapid advice guidelines for pharmacological management of sporadic human infection with avian influenza A (H5N1) virus
Auteurs : Holgsr J. Schünemann [Italie] ; Suzanne R. Hill [Suisse] ; Meetali Kakad [Norvège] ; Richard Bellamy [Royaume-Uni] ; Timothy M. Uyeki [Royaume-Uni] ; Frederick G. Hayden [États-Unis] ; Yazdan Yazdanpanah [États-Unis] ; John Beigel [Thaïlande] ; Tawee Chotpitayasunondh [Azerbaïdjan] ; Chris Del Mar [Australie, États-Unis] ; Jeremy Farrar [Viêt Nam] ; Tran Tinh Hien [France] ; Bülent Ozbay ; Norio Sugaya ; Keiji Fukuda ; Nikki Shindo ; Lauren Stockman [États-Unis] ; Gunn E. Vist [Norvège] ; Alice Croisier ; Azim Nagjdaliyev ; Cathy Roth ; Gail Thomson ; Howard Zucker [Suisse] ; Andrew D. Oxman [Norvège]Source :
- Lancet. Infectious diseases : (print) [ 1473-3099 ] ; 2007.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Recommandation, Homme.
English descriptors
- KwdEn :
Abstract
Recent spread of avian influenza A (H5N1) virus to poultry and wild birds has increased the threat of human infections with HSN1 virus worldwide. Despite international agreement to stockpile antivirals, evidence-based guidelines for their use do not exist. WHO assembled an international multidisdplinary panel to develop rapid advice for the pharmacological management of human H5N1 virus infection in the current pandemic alert period. A transparent methodological guideline process on the basis of the Grading Recommendations, Assessment, Development and Evaluation (GRADE) approach was used to develop evidence-based guidelines. Our development of specific recommendations for treatment and chemoprophylaxis of sporadic H5N1 infection resulted from the benefits, harms, burden, and cost of interventions in several patient and exposure groups. Overall, the quality of the underlying evidence for all recommendations was rated as very low because it was based on small case series of H5N1 patients, on extrapolation from preclinical studies, and high quality studies of seasonal influenza. A strong recommendation to treat H5N1 patients with oseltamivir was made in part because of the severity of the disease. Similarly, strong recommendations were made to use neuraminidase inhibitors as chemoprophylaxis in high-risk exposure populations. Emergence of other novel influenza A viral subtypes with pandemic potential, or changes in the pathogenicity of H5N1 virus strains, will require an update of these guidelines and WHO will be monitoring this closely.
Affiliations:
- Australie, Azerbaïdjan, France, Italie, Norvège, Royaume-Uni, Suisse, Thaïlande, Viêt Nam, États-Unis
- Latium, Østlandet
- Oslo, Rome
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Vist</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Norwegian Knowledge Centre for the Health Services</s1><s2>Oslo</s2><s3>NOR</s3><sZ>3 aut.</sZ><sZ>18 aut.</sZ><sZ>24 aut.</sZ></inist:fA14><country>Norvège</country><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Croisier, Alice" sort="Croisier, Alice" uniqKey="Croisier A" first="Alice" last="Croisier">Alice Croisier</name></author><author><name sortKey="Nagjdaliyev, Azim" sort="Nagjdaliyev, Azim" uniqKey="Nagjdaliyev A" first="Azim" last="Nagjdaliyev">Azim Nagjdaliyev</name></author><author><name sortKey="Roth, Cathy" sort="Roth, Cathy" uniqKey="Roth C" first="Cathy" last="Roth">Cathy Roth</name></author><author><name sortKey="Thomson, Gail" sort="Thomson, Gail" uniqKey="Thomson G" first="Gail" last="Thomson">Gail Thomson</name></author><author><name sortKey="Zucker, Howard" sort="Zucker, Howard" uniqKey="Zucker H" first="Howard" last="Zucker">Howard Zucker</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Health Technology and Pharmaceuticals, WHO</s1><s2>Geneva</s2><s3>CHE</s3><sZ>2 aut.</sZ><sZ>23 aut.</sZ></inist:fA14><country>Suisse</country><wicri:noRegion>Geneva</wicri:noRegion></affiliation></author><author><name sortKey="Oxman, Andrew D" sort="Oxman, Andrew D" uniqKey="Oxman A" first="Andrew D." last="Oxman">Andrew D. Oxman</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Norwegian Knowledge Centre for the Health Services</s1><s2>Oslo</s2><s3>NOR</s3><sZ>3 aut.</sZ><sZ>18 aut.</sZ><sZ>24 aut.</sZ></inist:fA14><country>Norvège</country><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">07-0047839</idno><date when="2007">2007</date><idno type="stanalyst">PASCAL 07-0047839 INIST</idno><idno type="RBID">Pascal:07-0047839</idno><idno type="wicri:Area/PascalFrancis/Corpus">003E71</idno><idno type="wicri:Area/PascalFrancis/Curation">002217</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">003515</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">003515</idno><idno type="wicri:doubleKey">1473-3099:2007:Schunemann H:who:rapid:advice</idno><idno type="wicri:Area/Main/Merge">009C27</idno><idno type="wicri:Area/Main/Curation">009252</idno><idno type="wicri:Area/Main/Exploration">009252</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">WHO rapid advice guidelines for pharmacological management of sporadic human infection with avian influenza A (H5N1) virus</title><author><name sortKey="Schunemann, Holgsr J" sort="Schunemann, Holgsr J" uniqKey="Schunemann H" first="Holgsr J." last="Schünemann">Holgsr J. Schünemann</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Italian National Cancer Institute Regina Elena, INFORMA Unit, Department of Epidemiology, Istituto Regina Elena</s1><s2>Rome</s2><s3>ITA</s3><sZ>1 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Hill, Suzanne R" sort="Hill, Suzanne R" uniqKey="Hill S" first="Suzanne R." last="Hill">Suzanne R. Hill</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Health Technology and Pharmaceuticals, WHO</s1><s2>Geneva</s2><s3>CHE</s3><sZ>2 aut.</sZ><sZ>23 aut.</sZ></inist:fA14><country>Suisse</country><wicri:noRegion>Geneva</wicri:noRegion></affiliation></author><author><name sortKey="Kakad, Meetali" sort="Kakad, Meetali" uniqKey="Kakad M" first="Meetali" last="Kakad">Meetali Kakad</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Norwegian Knowledge Centre for the Health Services</s1><s2>Oslo</s2><s3>NOR</s3><sZ>3 aut.</sZ><sZ>18 aut.</sZ><sZ>24 aut.</sZ></inist:fA14><country>Norvège</country><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Bellamy, Richard" sort="Bellamy, Richard" uniqKey="Bellamy R" first="Richard" last="Bellamy">Richard Bellamy</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Infection and Travel Medicine, James Cook University Hospital</s1><s2>Middlesbrough</s2><s3>GBR</s3><sZ>4 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Middlesbrough</wicri:noRegion></affiliation></author><author><name sortKey="Uyeki, Timothy M" sort="Uyeki, Timothy M" uniqKey="Uyeki T" first="Timothy M." last="Uyeki">Timothy M. Uyeki</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Oxford University Clinical Research Unit</s1><s3>GBR</s3><sZ>5 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Oxford University Clinical Research Unit</wicri:noRegion></affiliation></author><author><name sortKey="Hayden, Frederick G" sort="Hayden, Frederick G" uniqKey="Hayden F" first="Frederick G." last="Hayden">Frederick G. Hayden</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Respiratory and Enteric Viruses Branch, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention</s1><s2>Atlanta, GA</s2><s3>USA</s3><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Atlanta, GA</wicri:noRegion></affiliation></author><author><name sortKey="Yazdanpanah, Yazdan" sort="Yazdanpanah, Yazdan" uniqKey="Yazdanpanah Y" first="Yazdan" last="Yazdanpanah">Yazdan Yazdanpanah</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>National Institute of Health Clinical Center</s1><s2>Bethesda, MD</s2><s3>USA</s3><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>National Institute of Health Clinical Center</wicri:noRegion></affiliation></author><author><name sortKey="Beigel, John" sort="Beigel, John" uniqKey="Beigel J" first="John" last="Beigel">John Beigel</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Queen Sirikit National Institute of Child Health, MOPH</s1><s2>Bangkok</s2><s3>THA</s3><sZ>8 aut.</sZ></inist:fA14><country>Thaïlande</country><wicri:noRegion>Bangkok</wicri:noRegion></affiliation></author><author><name sortKey="Chotpitayasunondh, Tawee" sort="Chotpitayasunondh, Tawee" uniqKey="Chotpitayasunondh T" first="Tawee" last="Chotpitayasunondh">Tawee Chotpitayasunondh</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Children Clinical Hospital</s1><s2>Baku</s2><s3>AZE</s3><sZ>9 aut.</sZ></inist:fA14><country>Azerbaïdjan</country><wicri:noRegion>Children Clinical Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Del Mar, Chris" sort="Del Mar, Chris" uniqKey="Del Mar C" first="Chris" last="Del Mar">Chris Del Mar</name><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Faculty of Health Sciences and Medicine, Bond University</s1><s2>Gold Coast, Queensland</s2><s3>AUS</s3><sZ>10 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Gold Coast, Queensland</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Departments of Internal Medicine and Pathology, University of Virginia Health Sciences Center</s1><s2>Charlottesville, VA</s2><s3>USA</s3><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Charlottesville, VA</wicri:noRegion></affiliation></author><author><name sortKey="Farrar, Jeremy" sort="Farrar, Jeremy" uniqKey="Farrar J" first="Jeremy" last="Farrar">Jeremy Farrar</name><affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Hospital for Tropical Diseases</s1><s2>Hochi Minh City</s2><s3>VNM</s3><sZ>11 aut.</sZ></inist:fA14><country>Viêt Nam</country><wicri:noRegion>Hospital for Tropical Diseases</wicri:noRegion></affiliation></author><author><name sortKey="Hien, Tran Tinh" sort="Hien, Tran Tinh" uniqKey="Hien T" first="Tran Tinh" last="Hien">Tran Tinh Hien</name><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Service Universitaire des Maladies infectieuses, Pavillon Trousseau, CH Tourcoing, Faculté de Médecine de Lille</s1><s2>Tourcoing</s2><s3>FRA</s3><sZ>12 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Tourcoing</wicri:noRegion><wicri:noRegion>Faculté de Médecine de Lille</wicri:noRegion><wicri:noRegion>Tourcoing</wicri:noRegion></affiliation></author><author><name sortKey="Ozbay, Bulent" sort="Ozbay, Bulent" uniqKey="Ozbay B" first="Bülent" last="Ozbay">Bülent Ozbay</name></author><author><name sortKey="Sugaya, Norio" sort="Sugaya, Norio" uniqKey="Sugaya N" first="Norio" last="Sugaya">Norio Sugaya</name></author><author><name sortKey="Fukuda, Keiji" sort="Fukuda, Keiji" uniqKey="Fukuda K" first="Keiji" last="Fukuda">Keiji Fukuda</name></author><author><name sortKey="Shindo, Nikki" sort="Shindo, Nikki" uniqKey="Shindo N" first="Nikki" last="Shindo">Nikki Shindo</name></author><author><name sortKey="Stockman, Lauren" sort="Stockman, Lauren" uniqKey="Stockman L" first="Lauren" last="Stockman">Lauren Stockman</name><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention</s1><s2>Atlanta, GA</s2><s3>USA</s3><sZ>17 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Atlanta, GA</wicri:noRegion></affiliation></author><author><name sortKey="Vist, Gunn E" sort="Vist, Gunn E" uniqKey="Vist G" first="Gunn E." last="Vist">Gunn E. Vist</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Norwegian Knowledge Centre for the Health Services</s1><s2>Oslo</s2><s3>NOR</s3><sZ>3 aut.</sZ><sZ>18 aut.</sZ><sZ>24 aut.</sZ></inist:fA14><country>Norvège</country><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Croisier, Alice" sort="Croisier, Alice" uniqKey="Croisier A" first="Alice" last="Croisier">Alice Croisier</name></author><author><name sortKey="Nagjdaliyev, Azim" sort="Nagjdaliyev, Azim" uniqKey="Nagjdaliyev A" first="Azim" last="Nagjdaliyev">Azim Nagjdaliyev</name></author><author><name sortKey="Roth, Cathy" sort="Roth, Cathy" uniqKey="Roth C" first="Cathy" last="Roth">Cathy Roth</name></author><author><name sortKey="Thomson, Gail" sort="Thomson, Gail" uniqKey="Thomson G" first="Gail" last="Thomson">Gail Thomson</name></author><author><name sortKey="Zucker, Howard" sort="Zucker, Howard" uniqKey="Zucker H" first="Howard" last="Zucker">Howard Zucker</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Health Technology and Pharmaceuticals, WHO</s1><s2>Geneva</s2><s3>CHE</s3><sZ>2 aut.</sZ><sZ>23 aut.</sZ></inist:fA14><country>Suisse</country><wicri:noRegion>Geneva</wicri:noRegion></affiliation></author><author><name sortKey="Oxman, Andrew D" sort="Oxman, Andrew D" uniqKey="Oxman A" first="Andrew D." last="Oxman">Andrew D. Oxman</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Norwegian Knowledge Centre for the Health Services</s1><s2>Oslo</s2><s3>NOR</s3><sZ>3 aut.</sZ><sZ>18 aut.</sZ><sZ>24 aut.</sZ></inist:fA14><country>Norvège</country><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Lancet. Infectious diseases : (print)</title><title level="j" type="abbreviated">Lancet. Infect. dis. : (print)</title><idno type="ISSN">1473-3099</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Lancet. Infectious diseases : (print)</title><title level="j" type="abbreviated">Lancet. Infect. dis. : (print)</title><idno type="ISSN">1473-3099</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Avian influenza</term><term>Clinical management</term><term>Human</term><term>Influenza A</term><term>Recommendation</term><term>Sporadic</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Grippe A</term><term>Recommandation</term><term>Conduite à tenir</term><term>Sporadique</term><term>Homme</term><term>Grippe aviaire</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Recommandation</term><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Recent spread of avian influenza A (H5N1) virus to poultry and wild birds has increased the threat of human infections with HSN1 virus worldwide. Despite international agreement to stockpile antivirals, evidence-based guidelines for their use do not exist. WHO assembled an international multidisdplinary panel to develop rapid advice for the pharmacological management of human H5N1 virus infection in the current pandemic alert period. A transparent methodological guideline process on the basis of the Grading Recommendations, Assessment, Development and Evaluation (GRADE) approach was used to develop evidence-based guidelines. Our development of specific recommendations for treatment and chemoprophylaxis of sporadic H5N1 infection resulted from the benefits, harms, burden, and cost of interventions in several patient and exposure groups. Overall, the quality of the underlying evidence for all recommendations was rated as very low because it was based on small case series of H5N1 patients, on extrapolation from preclinical studies, and high quality studies of seasonal influenza. A strong recommendation to treat H5N1 patients with oseltamivir was made in part because of the severity of the disease. Similarly, strong recommendations were made to use neuraminidase inhibitors as chemoprophylaxis in high-risk exposure populations. Emergence of other novel influenza A viral subtypes with pandemic potential, or changes in the pathogenicity of H5N1 virus strains, will require an update of these guidelines and WHO will be monitoring this closely.</div></front></TEI><affiliations><list><country><li>Australie</li><li>Azerbaïdjan</li><li>France</li><li>Italie</li><li>Norvège</li><li>Royaume-Uni</li><li>Suisse</li><li>Thaïlande</li><li>Viêt Nam</li><li>États-Unis</li></country><region><li>Latium</li><li>Østlandet</li></region><settlement><li>Oslo</li><li>Rome</li></settlement></list><tree><noCountry><name sortKey="Croisier, Alice" sort="Croisier, Alice" uniqKey="Croisier A" first="Alice" last="Croisier">Alice Croisier</name><name sortKey="Fukuda, Keiji" sort="Fukuda, Keiji" uniqKey="Fukuda K" first="Keiji" last="Fukuda">Keiji Fukuda</name><name sortKey="Nagjdaliyev, Azim" sort="Nagjdaliyev, Azim" uniqKey="Nagjdaliyev A" first="Azim" last="Nagjdaliyev">Azim Nagjdaliyev</name><name sortKey="Ozbay, Bulent" sort="Ozbay, Bulent" uniqKey="Ozbay B" first="Bülent" last="Ozbay">Bülent Ozbay</name><name sortKey="Roth, Cathy" sort="Roth, Cathy" uniqKey="Roth C" first="Cathy" last="Roth">Cathy Roth</name><name sortKey="Shindo, Nikki" sort="Shindo, Nikki" uniqKey="Shindo N" first="Nikki" last="Shindo">Nikki Shindo</name><name sortKey="Sugaya, Norio" sort="Sugaya, Norio" uniqKey="Sugaya N" first="Norio" last="Sugaya">Norio Sugaya</name><name sortKey="Thomson, Gail" sort="Thomson, Gail" uniqKey="Thomson G" first="Gail" last="Thomson">Gail Thomson</name></noCountry><country name="Italie"><region name="Latium"><name sortKey="Schunemann, Holgsr J" sort="Schunemann, Holgsr J" uniqKey="Schunemann H" first="Holgsr J." last="Schünemann">Holgsr J. Schünemann</name></region></country><country name="Suisse"><noRegion><name sortKey="Hill, Suzanne R" sort="Hill, Suzanne R" uniqKey="Hill S" first="Suzanne R." last="Hill">Suzanne R. Hill</name></noRegion><name sortKey="Zucker, Howard" sort="Zucker, Howard" uniqKey="Zucker H" first="Howard" last="Zucker">Howard Zucker</name></country><country name="Norvège"><region name="Østlandet"><name sortKey="Kakad, Meetali" sort="Kakad, Meetali" uniqKey="Kakad M" first="Meetali" last="Kakad">Meetali Kakad</name></region><name sortKey="Oxman, Andrew D" sort="Oxman, Andrew D" uniqKey="Oxman A" first="Andrew D." last="Oxman">Andrew D. Oxman</name><name sortKey="Vist, Gunn E" sort="Vist, Gunn E" uniqKey="Vist G" first="Gunn E." last="Vist">Gunn E. Vist</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Bellamy, Richard" sort="Bellamy, Richard" uniqKey="Bellamy R" first="Richard" last="Bellamy">Richard Bellamy</name></noRegion><name sortKey="Uyeki, Timothy M" sort="Uyeki, Timothy M" uniqKey="Uyeki T" first="Timothy M." last="Uyeki">Timothy M. Uyeki</name></country><country name="États-Unis"><noRegion><name sortKey="Hayden, Frederick G" sort="Hayden, Frederick G" uniqKey="Hayden F" first="Frederick G." last="Hayden">Frederick G. Hayden</name></noRegion><name sortKey="Del Mar, Chris" sort="Del Mar, Chris" uniqKey="Del Mar C" first="Chris" last="Del Mar">Chris Del Mar</name><name sortKey="Stockman, Lauren" sort="Stockman, Lauren" uniqKey="Stockman L" first="Lauren" last="Stockman">Lauren Stockman</name><name sortKey="Yazdanpanah, Yazdan" sort="Yazdanpanah, Yazdan" uniqKey="Yazdanpanah Y" first="Yazdan" last="Yazdanpanah">Yazdan Yazdanpanah</name></country><country name="Thaïlande"><noRegion><name sortKey="Beigel, John" sort="Beigel, John" uniqKey="Beigel J" first="John" last="Beigel">John Beigel</name></noRegion></country><country name="Azerbaïdjan"><noRegion><name sortKey="Chotpitayasunondh, Tawee" sort="Chotpitayasunondh, Tawee" uniqKey="Chotpitayasunondh T" first="Tawee" last="Chotpitayasunondh">Tawee Chotpitayasunondh</name></noRegion></country><country name="Australie"><noRegion><name sortKey="Del Mar, Chris" sort="Del Mar, Chris" uniqKey="Del Mar C" first="Chris" last="Del Mar">Chris Del Mar</name></noRegion></country><country name="Viêt Nam"><noRegion><name sortKey="Farrar, Jeremy" sort="Farrar, Jeremy" uniqKey="Farrar J" first="Jeremy" last="Farrar">Jeremy Farrar</name></noRegion></country><country name="France"><noRegion><name sortKey="Hien, Tran Tinh" sort="Hien, Tran Tinh" uniqKey="Hien T" first="Tran Tinh" last="Hien">Tran Tinh Hien</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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